New research conducted suggests a compound that gives some cruciferous vegetables their pungent taste could help to reverse diabetes-associated kidney problems.
Experts estimate that about 25% of people with diabetes will eventually develop diabetic nephropathy, a gradual loss of kidney function eventually requiring dialysis. The condition is a leading cause of chronic kidney disease in the US and is also associated with a high risk of heart disease. There is no cure at this time.
For the new study, researchers assessed the effects of phenethyl isothiocyanate (PEITC) in rats with diabetic nephropathy. PEITC is found in several types of vegetables but is most concentrated in watercress.
"Our study provides, for the first time, evidence that PEITC might be effective as a naturally occurring agent to reverse serious kidney damage in people with diabetes," said lead study author Mohamed El-Sherbiny, Ph.D., a postdoctoral fellow at AlMaarefa University in Riyadh, Saudi Arabia.
Previous studies have suggested sulforaphane, a related compound in cruciferous vegetables, also helps reduce diabetes-associated kidney damage. The new study bolsters the evidence that eating more vegetables containing these compounds could help people with diabetes to stave off kidney problems.
"PEITC seems to manage one of the most serious and painful diabetic complications. Luckily, PEITC is naturally present in many dietary sources, importantly watercress, broccoli, turnips and radish," said El-Sherbiny.
Further studies will be needed to confirm the findings and understand how the results could translate to new treatments or dietary recommendations for people with diabetes.
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