Flagship Pioneering has unveiled Terrana Biosciences™, a company pioneering RNA-based agricultural solutions to deliver protective and enhanced crop traits without altering the plant genome.
Through its proprietary RNA technology platform, Terrana is developing targeted products designed to work at any time in a plant's lifecycle, enabling a continuous product pipeline that is adaptive and responsive to variable climate conditions and capable of generating new solutions at a fraction of the time and cost associated with conventional agriculture approaches. Flagship has initially committed $50 million to Terrana to scale operations and develop its first products in crop protection and yield.
"At Flagship Pioneering, we build groundbreaking platforms that address the world's most pressing challenges. With Terrana, we are bringing an entirely new dimension of innovation to agriculture through similar RNA technology that we pioneered in human health," said Noubar Afeyan, Ph.D., Co-Founder of Terrana, Founder and CEO of Flagship Pioneering. "This approach will empower farmers with precise, adaptive solutions to combat threats to crops in fields and orchards and enhance resiliency, sustainability, and productivity in the global food system."
Trees and crops naturally use a vast ecosystem of self-replicating RNAs to influence trait expression. These native RNAs are abundant, diverse, and are already part of the plant's own biology, functioning like a native language that helps to communicate traits like growth, stress response, and development. Using advanced AI and computational models, Terrana has assembled a vast library of RNAs and built a design system that enables efficient assembly of novel functional crop traits, generated with unprecedented precision, versatility and speed. The platform has already created three novel technology classes, demonstrated proof of concept in tomatoes, corn, and soy, and generated a pipeline of 15+ potential products in specialty and row crops.
"RNA-based technology has delivered lifesaving advancements in human health. We are now applying this same approach to reimagine what's possible for agriculture," said Ignacio Martinez, Co-Founder and Executive Chairman of Terrana and General Partner at Flagship Pioneering. "Using the language of nature, we can give plants new instructions, yielding adaptable solutions rooted directly in the plant's natural physiology. Our approach opens a new world of possibilities in annual and perennial crops for the benefit of farmers, people and the planet."
"Today, farmers make many important and costly decisions about seeds, fertilizers and crop protection before the crop year even begins, requiring them to rely on projections and historical trends from prior growing seasons rather than responding to real-time conditions on the ground," said Ryan Rapp, Co-Founder and CEO of Terrana Biosciences and Origination Partner at Flagship. "What's more, the increased pace of climate fluctuations and disease threats far exceeds today's slow and expensive R&D processes, leaving farmers all too often behind the curve. Terrana's ability to unlock all aspects of seed and crop traits in plants enables an entirely new set of agile solutions that can be applied at any time in the growing season, from seed to postharvest. In an increasingly unpredictable environment – from wildly fluctuating global markets to extreme weather events to fast-moving pest and disease pressures – farmers need these new tools to enable timely, efficient, nimble and, critically, cost-saving decision making."
For more information:
Terrana Biosciences 
terranabio.com/