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HotHouse Therapeutics:

UK: Vertical farms to mass produce rare medicinal drugs

"We imminently expect to close our seed funding round of more than £2.5m from a consortium of UK venture capital investors. The endgame for HotHouse Therapeutics will be the generation of novel plant-produced drugs, probably made in specifically engineered plant lines. Such lines will require secure facilities to grow the biomass needed for drug production. We are considering the potential of hydroponics and vertical farming in manufacturing our products. We are interested in engaging potential partners in this space and accessing development funding to explore routes to viable and sustainable production systems," says Martin Stocks, co-founder of HotHouse Therapeutics.

Plants produce some of the most potent drugs known to mankind, but issues such as accessing source material from rare plants and modifying complex chemicals have meant the drug discovery industry has largely abandoned them. This challenge has been overcome by HotHouse Therapeutics' technology, which enables any naturally occurring medicinal compound to be reproduced by a host plant, creating a high-value crop for CEA.

Martin continues, "HotHouse Therapeutics has the capability of isolating and reconstructing the entire biosynthetic pathway for any metabolite/chemical that is made by any plant or other organism. We can produce a compound of interest in our plant biofactory and modify the pathway to improve its properties. Plants have all the background chemistry and metabolic diversity to accept and operate biosynthetic pathways from other plants, animals, and microbes, making a plant remarkably flexible in its capabilities."

Martin Stocks

HotHouse Therapeutics was a spin-out from the laboratory of Professor Anne Osbourn OBE FRS at the John Innes Centre, following a breakthrough in understanding the biosynthesis of the vaccine adjuvant QS-21, used in vaccines for Covid 19, malaria, shingles, and RSV. It is one of the early-stage companies presenting in the Agri-TechE REAP 2023 Start-Up Showcase.

Adjuvants boost the immune system and are a critical component of all vaccines, but only a few have been approved by the US Food and Drugs Administration. QS-21 is currently extracted from the bark of the Chilean Soapbark Tree, and a single gram of the pure material costs more than $100,000. However, the tree bark also contains even more potent molecules that are present in such tiny amounts that they cannot be extracted at a commercial scale. With HotHouse Therapeutics' technology, these hyper-potent molecules can be synthesized in a biofactory, removing the need for extraction from wild trees and addressing a significant unmet need in the vaccine industry.

Read more about Professor Anne Osbourn's research here.

For more information:
REAP by Agri-TechE

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