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Fungal plant pathogens similar to flu viruses: difficult to be immune to them all

Developing plants that are immune to fungal diseases can perhaps best be compared to the development of flu vaccines. After all, making a plant immune to one form of fungus is not too hard but, just like flu viruses, fungal plant pathogens continue to develop new variants as they adapt to and elude the plant's immune system. It is this that often makes it difficult to grow plants that remain immune to a fungal pathogen over many years. Although it is possible, scientists need to work hard to achieve it, and growers need to grow plants with enough immune genes to prevent new outbreaks of disease. This was the subject of Pierre de Wit’s farewell address as Professor of Phytopathology at Wageningen University, part of Wageningen UR, on Thursday 5 June 2014.



In the 1980s and 1990s, Pierre de Wit and his research group were responsible for a better understanding of the gene-for-gene model in phytopathology. Fungi have genes that produce proteins, called effectors, which cause disease in plants. Luckily, some plants also have immune genes that produce receptors to recognise the effectors and so defend themselves against the fungus. When they do, the fungus is unable to develop and reproduce. To transfer this immunity, de Wit’s research group cross-fertilised wild species containing these immune genes with crops such as tomato plants.

Spontaneous mutation

Fungi are spread through the air using billions of spores – the seeds of the fungus. Because there are so many, there is always the chance of a spontaneous mutation, resulting in the fungus suddenly producing a slightly different effector protein. This protein is no longer recognised by the immune receptor, so that the pathogen can enter the plant and develop. When this altered pathogen produces spores, these spores will all make the new protein and therefore also no longer be recognised by the plant as an invader. The result is that all the plants of the same species in a particular area become diseased.

Click here to read the complete article at wageningenur.nl/en/
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