Karolinska Institutet, Sweden

Nano-sensor detects pesticides on fruit in minutes

Researchers at Karolinska Institutet in Sweden have developed a tiny sensor for detecting pesticides on fruit in just a few minutes. The technique, described as a proof-of-concept in a paper in the journal Advanced Science, uses flame-sprayed nanoparticles made from silver to increase the signal of chemicals. While still at an early stage, the researchers hope these nano-sensors could help uncover food pesticides before consumption.

“Reports show that up to half of all fruits sold in the EU contain pesticide residues that in larger quantities have been linked to human health problems,” says Georgios Sotiriou, principal researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, and the study’s corresponding author. “However, current techniques for detecting pesticides on single products before consumption are restricted in practice by the high cost and cumbersome manufacturing of its sensors. To overcome this, we developed inexpensive and reproducible nano-sensors that could be used to monitor traces of fruit pesticides at, for example, the store.”

The new nano-sensors employ a 1970s discovery known as surface-enhanced Raman scattering, or SERS, a powerful sensing technique that can increase the diagnostic signals of biomolecules on metal surfaces by more than 1 million times. The technology has been used in several research fields, including chemical and environmental analysis, as well as to detect biomarkers for various diseases. However, high production costs and limited batch-to-batch reproducibility have so far hindered widespread application in food safety diagnostics.

Flame spray technology
In the current study, the researchers created a SERS nano-sensor by using flame spray – a well-established and cost-effective technique for depositing metallic coating – to deliver small droplets of silver nanoparticles onto a glass surface.

“The flame spray can be used to quickly produce uniform SERS films across large areas, removing one of the key barriers to scalability,” says Haipeng Li, a postdoctoral researcher in Sotiriou’s lab and the study’s first author.

Detected pesticides on apples
To test the sensors’ practical application, the researchers calibrated them to detect low concentrations of parathion-ethyl, a toxic agricultural insecticide that is banned or restricted in most countries. A small amount of parathion-ethyl was placed on the part of an apple. The residues were later collected with a cotton swab that was immersed in a solution to dissolve the pesticide molecules. The solution was dropped on the sensor, which confirmed the presence of pesticides.

Next, the researchers want to explore if the nano-sensors can be applied to other areas, such as discovering biomarkers for specific diseases at the point of care in resource-limited settings.

The research was funded by the European Research Council (ERC), Karolinska Institutet, the Swedish Foundation for Strategic Research (SSF), and the Swedish Research Council.

For more information: eurekalert.org


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