- Significant cost reduction compared to traditional technologies
- The ability to read DNA molecules up to megabases in size
- The scalability and portability
- The potential to directly detect base modifications
That Nanopore sequencing has the ability to revolutionize sequencing is recently demonstrated by KeyGene’s publication: The megabase-sized fungal genome of Rhizoctonia solani assembled from nanopore reads only. KeyGene’s researchers involved in Nanopore sequencing are very enthusiastic about the results and possibilities of the technology:
“The ability to quickly obtain accurate genome sequences of eukaryotic pathogens at low costs provides a tremendous opportunity to identify novel targets for therapeutics, develop pesticides with increased target specificity and breed for resistance in food crops,” says Nathalie van Orsouw, VP Technology Development, KeyGene.
“Using the MinION sequencer we have demonstrated our ability to deliver a eukaryotic fungal genome sequence at low cost within a week. The upcoming PromethION system will enable KeyGene to cost-efficiently generate assemblies of both plant and pathogen genomes at population-scale and low cost,” says Erwin Datema, Scientist, KeyGene.
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